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Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains

Voltage-gated sodium, potassium, and calcium channels are made of a pore domain (PD) controlled by four voltage-sensing domains (VSDs). The PD contains the ion permeation pathway and the activation gate located on the intracellular side of the membrane. A large number of small molecules are known to...

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Autors principals: Hong, Liang, Pathak, Medha M., Kim, Iris H., Ta, Dennis, Tombola, Francesco
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559007/
https://ncbi.nlm.nih.gov/pubmed/23352164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.11.013
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