Topical Pazopanib Blocks VEGF-Induced Vascular Leakage and Neovascularization in the Mouse Retina but Is Ineffective in the Rabbit

PURPOSE. To test the effect of pazopanib, a tyrosine kinase inhibitor that blocks VEGF and platelet-derived growth factor (PDGF) receptors and c-Kit, on vascular leakage and neovascularization (NV) in the retina. METHODS. Pazopanib was tested to determine its effect on VEGF-induced vascular permeabi...

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Hlavní autoři: Iwase, Takeshi, Oveson, Brian C., Hashida, Noriyasu, Lima e Silva, Raquel, Shen, Jikui, Krauss, Achim H., Gale, David C., Adamson, Peter, Campochiaro, Peter A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558990/
https://ncbi.nlm.nih.gov/pubmed/23169884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10473
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