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Transgene-mediated suppression of the RNA interference pathway in Aedes aegypti interferes with gene silencing and enhances Sindbis virus and dengue virus type 2 replication

RNA interference (RNAi) is the major innate antiviral pathway in Aedes aegypti that responds to replicating arboviruses such as DENV and SINV. The mosquito’s RNAi machinery is capable of completely eliminating DENV2 from Ae. aegypti. On the other hand, transient silencing of key genes of the RNAi pa...

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Detalhes bibliográficos
Main Authors: Khoo, CCH, Doty, JB, Heersink, MS, Olson, KE, Franz, AWE
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558842/
https://ncbi.nlm.nih.gov/pubmed/23331493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imb.12008
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