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Transgene-mediated suppression of the RNA interference pathway in Aedes aegypti interferes with gene silencing and enhances Sindbis virus and dengue virus type 2 replication

RNA interference (RNAi) is the major innate antiviral pathway in Aedes aegypti that responds to replicating arboviruses such as DENV and SINV. The mosquito’s RNAi machinery is capable of completely eliminating DENV2 from Ae. aegypti. On the other hand, transient silencing of key genes of the RNAi pa...

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Bibliografski detalji
Glavni autori: Khoo, CCH, Doty, JB, Heersink, MS, Olson, KE, Franz, AWE
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558842/
https://ncbi.nlm.nih.gov/pubmed/23331493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imb.12008
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