CB(1) Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

We have previously identified allosteric modulators of the cannabinoid CB(1) receptor (Org 27569, PSNCBAM-1) that display a contradictory pharmacological profile: increasing the specific binding of the CB(1) receptor agonist [(3)H]CP55940 but producing a decrease in CB(1) receptor agonist efficacy....

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Main Authors: Baillie, Gemma L., Horswill, James G., Anavi-Goffer, Sharon, Reggio, Patricia H., Bolognini, Daniele, Abood, Mary E., McAllister, Sean, Strange, Phillip G., Stephens, Gary J., Pertwee, Roger G., Ross, Ruth A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558808/
https://ncbi.nlm.nih.gov/pubmed/23160940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080879
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