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CB(1) Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity
We have previously identified allosteric modulators of the cannabinoid CB(1) receptor (Org 27569, PSNCBAM-1) that display a contradictory pharmacological profile: increasing the specific binding of the CB(1) receptor agonist [(3)H]CP55940 but producing a decrease in CB(1) receptor agonist efficacy....
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558808/ https://ncbi.nlm.nih.gov/pubmed/23160940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080879 |
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