Bone vascularization and trabecular bone formation are mediated by PKBalpha/Akt1 in a gene dosage dependent manner: In vivo and ex vivo MRI

PKBalpha/Akt1, a protein kinase, is a major mediator of angiogenic signaling. The purpose of this study was to determine the role of PKBalpha/Akt1 in bone vascularization and development. For that aim, macromolecular dynamic contrast enhanced MRI (DCE-MRI) was applied to examine in vivo vascular cha...

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Bibliographic Details
Main Authors: Vandoorne, Katrien, Magland, Jeremy, Plaks, Vicki, Sharir, Amnon, Zelzer, Elazar, Wehrli, Felix, Hemmings, Brian A., Harmelin, Alon, Neeman, Michal
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558735/
https://ncbi.nlm.nih.gov/pubmed/20572141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.22395
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