Jab1/CSN5, a Component of the COP9 Signalosome, Regulates Transforming Growth Factor β Signaling by Binding to Smad7 and Promoting Its Degradation

Smad7 inhibits responses mediated by transforming growth factor β (TGF-β) and acts in a negative-feedback loop to regulate the intensity or duration of the TGF-β signal. However, the aberrant expression and continued presence of Smad7 may cause TGF-β resistance. Here we report that Jab1/CSN5, which...

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Detalhes bibliográficos
Main Authors: Kim, Byung-Chul, Lee, Ho-Jae, Park, Seok Hee, Lee, Sae Ra, Karpova, Tatiana S., McNally, James G., Felici, Angelina, Lee, Dug Keun, Kim, Seong-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC355855/
https://ncbi.nlm.nih.gov/pubmed/14993265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.6.2251-2262.2004
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