Stimulating β-Cell Regeneration by Combining a GPR119 Agonist with a DPP-IV Inhibitor

BACKGROUND: Activating G-protein coupled receptor 119 (GPR119) by its agonists can stimulate glucagon like peptide-1 (GLP-1) release. GLP-1 is rapidly degraded and inactivated by dipeptidylpeptidase-IV (DPP-IV). We studied the efficiency of combining PSN632408, a GPR119 agonist, with sitagliptin, a...

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Bibliografiske detaljer
Main Authors: Ansarullah, Lu, Yan, Holstein, Martha, DeRuyter, Brittany, Rabinovitch, Alex, Guo, Zhiguang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558424/
https://ncbi.nlm.nih.gov/pubmed/23382843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053345
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