sCD44 Internalization in Human Trabecular Meshwork Cells

PURPOSE. To determine whether soluble CD44 (sCD44), a likely biomarker of primary open-angle glaucoma (POAG), is internalized in cultured human trabecular meshwork (TM) cells and trafficked to mitochondria. METHODS. In vitro, 32-kD sCD44 was isolated from human sera, biotinylated, and dephosphorylat...

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Bibliografiske detaljer
Main Authors: Nolan, Michael J., Koga, Tomoyo, Walker, Loyal, McCarty, Ryan, Grybauskas, Algis, Giovingo, Michael C., Skuran, Kevin, Kuprys, Paulius V., Knepper, Paul A.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558300/
https://ncbi.nlm.nih.gov/pubmed/23287794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10627
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