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A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity

Lysosomal phospholipase A2 (group XV PLA2, LPLA2) is a lysosomal enzyme linked to drug induced phospholipidosis. We developed phospholipid “smart probes” based on the conversion of a quenched fluorogenic substrate to a fluorescent product. Due to the preference of LPLA2 for phosphatidylglycerol, thr...

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Bibliografiska uppgifter
Huvudupphovsmän: Abe, Akira, Rzepecki, Piotr W., Shayman, James A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557754/
https://ncbi.nlm.nih.gov/pubmed/23146589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2012.11.004
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