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A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity
Lysosomal phospholipase A2 (group XV PLA2, LPLA2) is a lysosomal enzyme linked to drug induced phospholipidosis. We developed phospholipid “smart probes” based on the conversion of a quenched fluorogenic substrate to a fluorescent product. Due to the preference of LPLA2 for phosphatidylglycerol, thr...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557754/ https://ncbi.nlm.nih.gov/pubmed/23146589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2012.11.004 |
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