Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

Endoxifen, a cytochrome P450 mediated tamoxifen metabolite, is being developed as a drug for the treatment of estrogen receptor (ER) positive breast cancer. Endoxifen is known to be a potent anti-estrogen and its mechanisms of action are still being elucidated. Here, we demonstrate that endoxifen-me...

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Bibliographische Detailangaben
Hauptverfasser: Hawse, John R., Subramaniam, Malayannan, Cicek, Muzaffer, Wu, Xianglin, Gingery, Anne, Grygo, Sarah B., Sun, Zhifu, Pitel, Kevin S., Lingle, Wilma L., Goetz, Matthew P., Ingle, James N., Spelsberg, Thomas C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557294/
https://ncbi.nlm.nih.gov/pubmed/23382923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054613
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