Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

Endoxifen, a cytochrome P450 mediated tamoxifen metabolite, is being developed as a drug for the treatment of estrogen receptor (ER) positive breast cancer. Endoxifen is known to be a potent anti-estrogen and its mechanisms of action are still being elucidated. Here, we demonstrate that endoxifen-me...

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Detalhes bibliográficos
Main Authors: Hawse, John R., Subramaniam, Malayannan, Cicek, Muzaffer, Wu, Xianglin, Gingery, Anne, Grygo, Sarah B., Sun, Zhifu, Pitel, Kevin S., Lingle, Wilma L., Goetz, Matthew P., Ingle, James N., Spelsberg, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557294/
https://ncbi.nlm.nih.gov/pubmed/23382923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054613
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