Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen

INTRODUCTION: We have previously demonstrated that endoxifen is the most important tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). However, the relevance of ERβ in mediating endoxifen action has...

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Hlavní autoři: Wu, Xianglin, Subramaniam, Malayannan, Grygo, Sarah B, Sun, Zhifu, Negron, Vivian, Lingle, Wilma L, Goetz, Matthew P, Ingle, James N, Spelsberg, Thomas C, Hawse, John R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219188/
https://ncbi.nlm.nih.gov/pubmed/21392396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2844
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