Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson’s disease

OBJECTIVE: In MPTP animal models of Parkinson’s disease (PD), caffeine protects neurons by blocking the adenosine receptor A2A (ADORA2A). Caffeine is primarily metabolized by cytochrome P450 1A2 (CYP1A2). Our objective was to examine whether ADORA2A and CYP1A2 polymorphisms are associated with PD ri...

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Detaylı Bibliyografya
Asıl Yazarlar: Popat, R.A., Van Den Eeden, S.K., Tanner, C.M., Kamel, F., Umbach, D. M., Marder, K., Mayeux, R., Ritz, B., Ross, G. Webster, Petrovitch, H., Topol, B., McGuire, V., Costello, Sadie, Manthripragada, Angelika.D., Southwick, A., Myers, R.M., Nelson, L. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556904/
https://ncbi.nlm.nih.gov/pubmed/21281405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1468-1331.2011.03353.x
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