The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype

AIMS: 1) To determine the pharmacokinetics and pharmacodynamics of (R)- and (S)-warfarin given alone and in combination and 2) to determine whether the relative potency of (R)- and (S)-warfarin is dependent on VKORC1 genotype. METHODS: A three way crossover study was conducted in which 17 healthy ma...

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Detalhes bibliográficos
Main Authors: Maddison, John, Somogyi, Andrew A, Jensen, Berit P, James, Heather M, Gentgall, Melanie, Rolan, Paul E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Phamacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555060/
https://ncbi.nlm.nih.gov/pubmed/22616655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04335.x
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