Dual Role of an N-terminal Amyloidogenic Mutation in Apolipoprotein A-I: DESTABILIZATION OF HELIX BUNDLE AND ENHANCEMENT OF FIBRIL FORMATION

A number of naturally occurring mutations of apolipoprotein (apo) A-I, the major protein of HDL, are known to be associated with hereditary amyloidosis and atherosclerosis. Here, we examined the effects of the G26R point mutation in apoA-I (apoA-I(Iowa)) on the structure, stability, and aggregation...

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Detalhes bibliográficos
Main Authors: Adachi, Emi, Nakajima, Hiroyuki, Mizuguchi, Chiharu, Dhanasekaran, Padmaja, Kawashima, Hiroyuki, Nagao, Kohjiro, Akaji, Kenichi, Lund-Katz, Sissel, Phillips, Michael C., Saito, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554949/
https://ncbi.nlm.nih.gov/pubmed/23233678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428052
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