Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation

The ubiquitin-like molecule ISG15 (UCRP) and protein modification by ISG15 (ISGylation) are strongly induced by interferon, genotoxic stress, and pathogen infection, suggesting that ISG15 plays an important role in innate immune responses. However, how ISGylation contributes to innate immune respons...

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Detalhes bibliográficos
Main Authors: Okumura, Fumihiko, Okumura, Akiko J., Uematsu, Keiji, Hatakeyama, Shigetsugu, Zhang, Dong-Er, Kamura, Takumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554948/
https://ncbi.nlm.nih.gov/pubmed/23229543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401851
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