Toll-like Receptor Agonists and Febrile Range Hyperthermia Synergize to Induce Heat Shock Protein 70 Expression and Extracellular Release

Heat shock protein (Hsp) 70 expression can be stimulated by febrile range temperature (FRT). Hsp70 has been shown to be elevated in serum of patients with sepsis, and when released from cells, extracellular Hsp70 exerts endotoxin-like effects through Toll-like receptor 4 (TLR4) receptors. Circulatin...

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Autores principales: Gupta, Aditi, Cooper, Zachary A., Tulapurkar, Mohan E., Potla, Ratnakar, Maity, Tapan, Hasday, Jeffrey D., Singh, Ishwar S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554941/
https://ncbi.nlm.nih.gov/pubmed/23212905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427336
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