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Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells

Expression of heat shock proteins (HSPs) is classically activated at temperatures above the physiologic range (≥42°C) via activation of the stress-activated transcription factor, heat shock factor-1 (HSF-1). Several studies suggest that less extreme hyperthermia, especially within the febrile range,...

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Autors principals: Tulapurkar, Mohan E., Asiegbu, Benedict E., Singh, Ishwar S., Hasday, Jeffrey D.
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728283/
https://ncbi.nlm.nih.gov/pubmed/19221897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-009-0103-3
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