Pathogenic Serum Amyloid A 1.1 Shows a Long Oligomer-rich Fibrillation Lag Phase Contrary to the Highly Amyloidogenic Non-pathogenic SAA2.2

Serum amyloid A (SAA) is best known for being the main component of amyloid in the inflammation-related disease amyloid A (AA) amyloidosis. Despite the high sequence identity among different SAA isoforms, not all SAA proteins are pathogenic. In most mouse strains, the AA deposits mostly consist of S...

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Detalhes bibliográficos
Main Authors: Srinivasan, Saipraveen, Patke, Sanket, Wang, Yun, Ye, Zhuqiu, Litt, Jeffrey, Srivastava, Sunit K., Lopez, Maria M., Kurouski, Dmitry, Lednev, Igor K., Kane, Ravi S., Colón, Wilfredo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554940/
https://ncbi.nlm.nih.gov/pubmed/23223242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394155
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