The V499G/Y501H Mutation Impairs Fast Motor Kinetics of Prestin and Has Significance for Defining Functional Independence of Individual Prestin Subunits

Outer hair cells (OHCs) are a mammalian innovation for mechanically amplifying sound energy to overcome the viscous damping of the cochlear partition. Although the voltage-dependent OHC membrane motor, prestin, has been demonstrated to be essential for mammalian cochlear amplification, the molecular...

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Bibliografiska uppgifter
Huvudupphovsmän: Homma, Kazuaki, Duan, Chongwen, Zheng, Jing, Cheatham, Mary Ann, Dallos, Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Molecular Biophysics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554914/
https://ncbi.nlm.nih.gov/pubmed/23212912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411579
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