In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion

Early-stage type 1 diabetes (T1D) exhibits hyperglucagonemia by undefined cellular mechanisms. Here we characterized α-cell voltage-gated ion channels in a streptozotocin (STZ)-induced diabetes model that lead to increased glucagon secretion mimicking T1D. GYY mice expressing enhanced yellow fluores...

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Главные авторы: Huang, Ya-Chi, Rupnik, Marjan S., Karimian, Negar, Herrera, Pedro L., Gilon, Patrick, Feng, Zhong-Ping, Gaisano, Herbert Y.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2013
Предметы:
Islet Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554363/
https://ncbi.nlm.nih.gov/pubmed/23043159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0786
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