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Mouse Dendritic Cell (DC) Influenza Virus Infectivity Is Much Lower than That for Human DCs and Is Hemagglutinin Subtype Dependent

We show that influenza A H1N1 virus infection leads to very low infectivity in mouse dendritic cells (DCs) in vitro compared with that in human DCs. This holds when H3 or H5 replaces H1 in recombinant viruses. Viruslike particles confirm the difference between mouse and human, suggesting that reduce...

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Bibliografiske detaljer
Main Authors: Hartmann, Boris M., Li, Wenjing, Jia, Jingjing, Patil, Sonali, Marjanovic, Nada, Martínez-Romero, Carles, Albrecht, Randy A., Hayot, Fernand, García-Sastre, Adolfo, Wetmur, James G., Moran, Thomas M., Sealfon, Stuart C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554152/
https://ncbi.nlm.nih.gov/pubmed/23192878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02980-12
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