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Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner

DJ-1 is an oncogene and the causative gene for familial Parkinson's disease. Although the oxidative status of DJ-1 at cysteine 106 (C106) is thought to affect all of the activities of DJ-1 and excess oxidation leads to the onset of various diseases, the precise molecular mechanisms underlying t...

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Bibliografiske detaljer
Main Authors: Kato, Izumi, Maita, Hiroshi, Takahashi-Niki, Kazuko, Saito, Yoshiro, Noguchi, Noriko, Iguchi-Ariga, Sanae M. M., Ariga, Hiroyoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554126/
https://ncbi.nlm.nih.gov/pubmed/23149933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01350-12
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