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Fat Body dSir2 Regulates Muscle Mitochondrial Physiology and Energy Homeostasis Nonautonomously and Mimics the Autonomous Functions of dSir2 in Muscles

Sir2 is an evolutionarily conserved NAD(+)-dependent deacetylase which has been shown to play a critical role in glucose and fat metabolism. In this study, we have perturbed Drosophila Sir2 (dSir2) expression, bidirectionally, in muscles and the fat body. We report that dSir2 plays a critical role i...

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Bibliografiske detaljer
Main Authors: Banerjee, Kushal K., Ayyub, Champakali, Sengupta, Samudra, Kolthur-Seetharam, Ullas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554107/
https://ncbi.nlm.nih.gov/pubmed/23129806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00976-12
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