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Cyclin T1 and CDK9 T-Loop Phosphorylation Are Downregulated during Establishment of HIV-1 Latency in Primary Resting Memory CD4(+) T Cells

P-TEFb, a cellular kinase composed of Cyclin T1 and CDK9, is essential for processive HIV-1 transcription. P-TEFb activity is dependent on phosphorylation of Thr186 in the CDK9 T loop. In resting CD4(+) T cells which are nonpermissive for HIV-1 replication, the levels of Cyclin T1 and T-loop-phospho...

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Detaylı Bibliyografya
Asıl Yazarlar: Budhiraja, Sona, Famiglietti, Marylinda, Bosque, Alberto, Planelles, Vicente, Rice, Andrew P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554045/
https://ncbi.nlm.nih.gov/pubmed/23152527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02413-12
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