Viral Genome Methylation Differentially Affects the Ability of BZLF1 versus BRLF1 To Activate Epstein-Barr Virus Lytic Gene Expression and Viral Replication

The Epstein-Barr virus (EBV) immediate-early proteins BZLF1 and BRLF1 can both induce lytic EBV reactivation when overexpressed in latently infected cells. Although EBV genome methylation is required for BZLF1-mediated activation of lytic gene expression, the effect of viral genome methylation on BR...

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Main Authors: Wille, Coral K., Nawandar, Dhananjay M., Panfil, Amanda R., Ko, Michelle M., Hagemeier, Stacy R., Kenney, Shannon C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554042/
https://ncbi.nlm.nih.gov/pubmed/23135711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01790-12
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