Population Pharmacokinetic and Pharmacodynamic Properties of Intramuscular Quinine in Tanzanian Children with Severe Falciparum Malaria

Although artesunate is clearly superior, parenteral quinine is still used widely for the treatment of severe malaria. A loading-dose regimen has been recommended for 30 years but is still often not used. A population pharmacokinetic study was conducted with 75 Tanzanian children aged 4 months to 8 y...

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Bibliographic Details
Main Authors: Hendriksen, Ilse C. E., Maiga, Deogratius, Lemnge, Martha M., Mtove, George, Gesase, Samwel, Reyburn, Hugh, Lindegardh, Niklas, Day, Nicholas P. J., von Seidlein, Lorenz, Dondorp, Arjen M., Tarning, Joel, White, Nicholas J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Clinical Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553700/
https://ncbi.nlm.nih.gov/pubmed/23183442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01349-12
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