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ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress

Faithful DNA replication is essential for normal cell division and differentiation. In eukaryotic cells, DNA replication takes place on chromatin. This poses the critical question as to how DNA replication can progress through chromatin, which is inhibitory to all DNA-dependent processes. Here, we d...

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Hlavní autoři: Rodriguez, Jairo, Tsukiyama, Toshio
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553285/
https://ncbi.nlm.nih.gov/pubmed/23307868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.202978.112
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