PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

BACKGROUND: It has been reported that peroxisome proliferator-activated receptor (PPAR)-γ and their synthetic ligands have direct effects on pancreatic β-cells. We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in pancreatic β-cells. METHODS: R...

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Hlavní autoři: Kim, Hyo-Sup, Hwang, You-Cheol, Koo, Seung-Hoi, Park, Kyong Soo, Lee, Myung-Shik, Kim, Kwang-Won, Lee, Moon-Kyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553172/
https://ncbi.nlm.nih.gov/pubmed/23372643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050128
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