Activation of CD11b(+) Kupffer Cells/Macrophages as a Common Cause for Exacerbation of TNF/Fas-Ligand-Dependent Hepatitis in Hypercholesterolemic Mice

We have reported that the mouse hepatic injury induced by either α-galactosylceramide (α-GalCer) or bacterial DNA motifs (CpG-ODN) is mediated by the TNF/NKT cell/Fas-ligand (FasL) pathway. In addition, F4/80(+) Kupffer cells can be subclassified into CD68(+) subset with a phagocytosing capacity and...

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Bibliographic Details
Main Authors: Nakashima, Hiroyuki, Ogawa, Yoshiko, Shono, Satoshi, Kinoshita, Manabu, Nakashima, Masahiro, Sato, Atsushi, Ikarashi, Masami, Seki, Shuhji
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553091/
https://ncbi.nlm.nih.gov/pubmed/23372642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049339
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