Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

Hepatitis C virus (HCV) is able to induce autophagy via endoplasmic reticulum (ER) stress, but the exact molecular signaling pathway is not well understood. We found that the activity of the mechanistic target of rapamycin complex 1 (MTORC1) was inhibited in Huh7 cells either harboring HCV-N (genoty...

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Hlavní autoři: Huang, He, Kang, Rongyan, Wang, Ji, Luo, Guangxiang, Yang, Wei, Zhao, Zhendong
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
Basic Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552882/
https://ncbi.nlm.nih.gov/pubmed/23169238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22791
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