Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury

Sepsis is a leading cause of intensive care unit admissions with high mortality and morbidity. Although outcomes have improved with better supportive care, specific therapies are limited. Endothelial activation and oxidant injury are key events in the pathogenesis of sepsis-induced lung injury. The...

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Bibliografiske detaljer
Main Authors: Mannam, Praveen, Zhang, Xuchen, Shan, Peiying, Zhang, Yi, Shinn, Amanda S., Zhang, Yitao, Lee, Patty J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552142/
https://ncbi.nlm.nih.gov/pubmed/23275604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202012
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