Combined action of Nucleic Acid-Sensing Toll-Like Receptors (TLRs) and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice

“Triple-defective” (3d) mice carrying a mutation in UNC93B1, a chaperone for the endosomal nucleic-acid sensing (NAS) Toll-Like Receptors TLR3, TLR7 and TLR9, are highly susceptible to Toxoplasma gondii infection. However, none of the single or even the triple NAS-TLR deficient animals recapitulated...

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Main Authors: Andrade, Warrison A., Souza, Maria do Carmo, Martinez, Espiridion R., Nagpal, Kamalpreet, Dutra, Miriam S., Melo, Mariane B., Bartholomeu, Daniella C., Ghosh, Sankar, Golenbock, Douglas T., Gazzinelli, Ricardo T.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552114/
https://ncbi.nlm.nih.gov/pubmed/23290966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.12.003
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