Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activation, immune defense mechanisms that are linked to immunopathology. Here we show that IFN-γ production by CD4(+) T(H)1 cells during mucosal responses to the protozoan parasite Toxoplasma gondii result...

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Detalhes bibliográficos
Main Authors: Raetz, Megan, Hwang, Sun-hee, Wilhelm, Cara, Kirkland, Donna, Benson, Alicia, Sturge, Carolyn, Mirpuri, Julie, Vaishnava, Shipra, Hou, Baidong, DeFranco, Anthony L., Gilpin, Christopher J, Hooper, Lora V., Yarovinsky, Felix
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552073/
https://ncbi.nlm.nih.gov/pubmed/23263554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2508
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