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Elevated Copper Binding Strength of Amyloid-β Aggregates Enables Their Copper Sequestration from Albumin: a Pathway to Accumulation of Copper in Senile Plaques
Copper coexists with amyloid-β (Aβ) peptides at a high concentration in the senile plaques of Alzheimer’s disease (AD) patients and has been linked to oxidative damage associated with AD pathology. However, the origin of copper and the driving force behind its accumulation are unknown. We designed a...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552001/ https://ncbi.nlm.nih.gov/pubmed/23237523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301053h |
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