Elevated Copper Binding Strength of Amyloid-β Aggregates Enables Their Copper Sequestration from Albumin: a Pathway to Accumulation of Copper in Senile Plaques

Copper coexists with amyloid-β (Aβ) peptides at a high concentration in the senile plaques of Alzheimer’s disease (AD) patients and has been linked to oxidative damage associated with AD pathology. However, the origin of copper and the driving force behind its accumulation are unknown. We designed a...

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Detalhes bibliográficos
Main Authors: Jiang, Dianlu, Zhang, Lin, Grant, Gian Paola G., Dudzik, Christopher G., Chen, Shu, Patel, Sveti, Hao, Yuanqiang, Millhauser, Glenn L., Zhou, Feimeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552001/
https://ncbi.nlm.nih.gov/pubmed/23237523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301053h
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