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Single molecule FRET shows uniformity in TBP-induced DNA bending and heterogeneity in bending kinetics()

TATA binding protein (TBP) is a key component of the eukaryotic RNA polymerase II (Pol II) transcription machinery that binds to TATA boxes located in the core promoter regions of many genes. Structural and biochemical studies have shown that when TBP binds DNA, it sharply bends the DNA. We used sin...

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Detalhes bibliográficos
Main Authors: Blair, Rebecca H., Goodrich, James A., Kugel, Jennifer F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551999/
https://ncbi.nlm.nih.gov/pubmed/22934924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300491j
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