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Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

BACKGROUND: The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non–small-cell lung cancer is effective but limited by the emergence of drug-resistance mutations. Molecular characterization of circulating tumor cells may provide a strateg...

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Autors principals: Maheswaran, Shyamala, Sequist, Lecia V., Nagrath, Sunitha, Ulkus, Lindsey, Brannigan, Brian, Collura, Chey V., Inserra, Elizabeth, Diederichs, Sven, Iafrate, A. John, Bell, Daphne W., Digumarthy, Subba, Muzikansky, Alona, Irimia, Daniel, Settleman, Jeffrey, Tompkins, Ronald G., Lynch, Thomas J., Toner, Mehmet, Haber, Daniel A.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551471/
https://ncbi.nlm.nih.gov/pubmed/18596266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0800668
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