Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

BACKGROUND: The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non–small-cell lung cancer is effective but limited by the emergence of drug-resistance mutations. Molecular characterization of circulating tumor cells may provide a strateg...

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Detalhes bibliográficos
Main Authors: Maheswaran, Shyamala, Sequist, Lecia V., Nagrath, Sunitha, Ulkus, Lindsey, Brannigan, Brian, Collura, Chey V., Inserra, Elizabeth, Diederichs, Sven, Iafrate, A. John, Bell, Daphne W., Digumarthy, Subba, Muzikansky, Alona, Irimia, Daniel, Settleman, Jeffrey, Tompkins, Ronald G., Lynch, Thomas J., Toner, Mehmet, Haber, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551471/
https://ncbi.nlm.nih.gov/pubmed/18596266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0800668
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