Conformation-Dependent Oligomers in Cerebrospinal Fluid of Presymptomatic Familial Alzheimer's Disease Mutation Carriers

BACKGROUND/AIMS: Oligomerization of amyloid beta (Aβ) is a hypothesized step in the formation of plaques in Alzheimer's disease (AD) but has been difficult to demonstrate in vivo in humans. As persons destined to develop familial AD (FAD) due to fully penetrant autosomal dominant mutations are...

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Detaylı Bibliyografya
Asıl Yazarlar: Ringman, John M., Tomic, Jennifer L., Coppola, Giovanni, Elashoff, David, Gylys, Karen H., Glabe, Charles G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: S. Karger AG 2012
Konular:
Original Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551434/
https://ncbi.nlm.nih.gov/pubmed/23341831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000345771
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