Metabolically Competent Human Skin Models: Activation and Genotoxicity of Benzo[a]pyrene

The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) is formed to certain extents. Skin is frequently in contact with PAHs and data on the metabolic capacity...

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Bibliographic Details
Main Authors: Brinkmann, Joep, Stolpmann, Kristin, Trappe, Susanne, Otter, Timo, Genkinger, Doris, Bock, Udo, Liebsch, Manfred, Henkler, Frank, Hutzler, Christoph, Luch, Andreas
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551429/
https://ncbi.nlm.nih.gov/pubmed/23148024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs316
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