Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis

In this study, we have analysed the apoptotic effects of the ubiquitous environmental toxin benzo[a]pyrene (BP) in HaCaT cells and human keratinocytes. Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fas)-mediated apoptosis was observed with BP at concen...

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Main Authors: Stolpmann, K, Brinkmann, J, Salzmann, S, Genkinger, D, Fritsche, E, Hutzler, C, Wajant, H, Luch, A, Henkler, F
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461363/
https://ncbi.nlm.nih.gov/pubmed/22951985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.127
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