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High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington’s Disease Model

A hallmark of Huntington’s disease is the presence of a large polyglutamine expansion in the first exon of the Huntingtin protein and the propensity of protein aggregation by the mutant proteins. Aberrant protein aggregation also occurs in other polyglutamine expansion disorders, as well as in other...

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Hlavní autoři: Titus, Steven A, Southall, Noel, Marugan, Juan, Austin, Christopher P, Zheng, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Bentham Open 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551243/
https://ncbi.nlm.nih.gov/pubmed/23346268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875397301206010079
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