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Chromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells
Many mitotic factors were shown to be activated by Ran guanosine triphosphatase. Previous studies in Xenopus laevis egg extracts and in highly proliferative cells showed that mitotic chromosomes were surrounded by steep Ran guanosine triphosphate (GTP) concentration gradients, indicating that RanGTP...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549973/ https://ncbi.nlm.nih.gov/pubmed/23319601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206142 |
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