A Recombinant Fusion Toxin Based on Enzymatic Inactive C3bot1 Selectively Targets Macrophages

BACKGROUND: The C3bot1 protein (∼23 kDa) from Clostridium botulinum ADP-ribosylates and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes/macrophages but not of other cell types such as epithelial cells or fibroblasts. Most likely, the internalization occurs by a...

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Bibliografiske detaljer
Main Authors: Dmochewitz, Lydia, Förtsch, Christina, Zwerger, Christian, Vaeth, Martin, Felder, Edward, Huber-Lang, Markus, Barth, Holger
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549961/
https://ncbi.nlm.nih.gov/pubmed/23349915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054517
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