Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins

Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor protein that traffics synaptic vesicles. Neurons lacking Dcx and/or its structur...

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Autori principali: Liu, Judy S., Schubert, Christian R., Fu, Xiaoqin, Fourniol, Franck J., Jaiswal, Jyoti K., Houdusse, Anne, Stultz, Collin M., Moores, Carolyn A., Walsh, Christopher A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549492/
https://ncbi.nlm.nih.gov/pubmed/22857951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.06.025
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