Efficient Intracellular siRNA Delivery by Ethyleneimine-Modified Amphiphilic Macromolecules

New materials that can bind and deliver oligonucleotides such as short interfering RNA (siRNA) without toxicity are greatly needed to fulfill the promise of therapeutic gene silencing. Amphiphilic macromolecules (AMs) were functionalized with linear ethyleneimines to create cationic AMs capable of c...

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Autores principales: Sparks, Sarah M., Waite, Carolyn L., Harmon, Alexander M., Nusblat, Leora M., Roth, Charles M., Uhrich, Kathryn E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549469/
https://ncbi.nlm.nih.gov/pubmed/21793212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mabi.201100064
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