mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

BACKGROUND: The mammalian target of rapamycin (mTOR) signalling pathway has a key role in cellular regulation and several diseases. While it is thought that Rheb GTPase regulates mTOR, acting immediately upstream, while raptor is immediately downstream of mTOR, direct interactions have yet to be ver...

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Detalhes bibliográficos
Main Authors: Yadav, Rahul B, Burgos, Pierre, Parker, Anthony W, Iadevaia, Valentina, Proud, Christopher G, Allen, Rodger A, O'Connell, James P, Jeshtadi, Ananya, Stubbs, Christopher D, Botchway, Stanley W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549280/
https://ncbi.nlm.nih.gov/pubmed/23311891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-14-3
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