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IgG-Enzyme Fusion Protein: Pharmacokinetics and Anti-Drug Antibody Response in Rhesus Monkeys
The chronic administration of recombinant fusion proteins in preclinical animal models may generate an immune response and the formation of anti-drug antibodies (ADA). Such ADAs could alter the plasma pharmacokinetics of the fusion protein, and mask any underlying toxicity of the recombinant fusion...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549264/ https://ncbi.nlm.nih.gov/pubmed/23249376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc3005123 |
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